2021.11.20 来源:化学与药学院 浏览数:0
肖建,男,教授,硕士研究生导师。泰山学者青年专家,山东省杰出青年基金获得者, 山东省青年科技领军人才,山东省高层次人才惠才卡获得者,青岛市高层次人才绿卡获得者,山东省青年科技奖获得者。1981年6月生,山东昌乐人,中共党员。2002年本科毕业于曲阜师范大学,2005年硕士毕业于南开大学,2009年博士毕业于新加坡南洋理工大学。2009-2010年在南洋理工大学从事博士后研究。2010-2012年在中国科学院大连化学物理研究所任副研究员。2013-2014年在美国加利福尼亚州The Scripps Research Institute做博士后研究。2012年9月以高层次人才引进至青岛农业大学化学与药学院工作,现为青岛农业大学功能有机分子团队负责人和有机化学学科带头人, 山东省优秀硕士论文指导教师, 青岛农业大学优秀学士论文指导教师, 青岛农业大学研究生创新计划指导教师, 国家大学生创新创业训练计划指导教师。中国化学会会员,山东省青年科技创新协会会员,山东省高端化工产业委员会秘书长,山东省化学化工学会监事会监事,青岛农业大学化学工艺二级学科硕士点负责人。迄今为止,已经以第一或通讯作者在Angew. Chem. Int. Ed.、Chem. Sci.等国际顶尖或权威期刊上发表SCI论文近70篇,ESI高被引论文6篇,他引总次数超过1200次,最高单篇他引234次。主持国家自然科学基金面上项目、泰山学者青年专家项目、山东省杰出青年基金等项目11项,授权国际PCT专利2项, 授权国内发明专利近20项,受邀撰写英文综述8篇,主编英文学术著作一部。先后荣获Asian Core Program Lectureship Award、山东省青年科技奖、山东省高等学校科学技术一等奖、山东省自然科学学术创新奖、长和国际奖教学金、中国科学院大连化学与物理研究所科技创新奖等荣誉。
教育背景
1998-2002 曲阜师范大学化学与化工学院 学士
2002-2005 南开大学元素有机化学研究所 硕士
2005-2009 新加坡南洋理工大学化学与生物化学系博士 (Prof Teck-Peng Loh)
工作经历
2009-2010 新加坡南洋理工大学化学与生物化学系博士后 (Prof Teck-Peng Loh)
2010-2012 中国科学院大连化学与物理研究所副研究员
2013-2014 美国The Scripps Research Institute博士后 (Carlos F. Barbas III)
科研项目
国家自然科学基金 21102142, 21702117, 21776148,21878167
国家重点研发计划 2017YFE0105200
农业部948计划 2016-X28
山东省自然科学杰出青年基金 JQ201604
山东省重点研发计划公益类专项 2017GSF218073 2018GSF118224
山东省自然科学基金面上项目 ZR2016BM07
山东省自然科学基金博士基金 ZR2017BB005
山东省中青年科学家奖励基金 BS2013YY002
青岛市应用基础研究计划青年科技专项14-2-4-70-jch
青岛市应用基础研究计划科技惠民专项 16-6-2-29-nsh
药物合成与优化湖北省重点实验室开放基金 OPP2015YB01, OPP2015ZD02
青岛农业大学高层次人才启动基金 6631112323,6631115015
青岛农业大学研究生创新计划QYC201616
国家大学生创新创业训练计划201410435050
企业横向课题 6602419032
荣誉奖励
2021 山东省自然科学二等奖(首位)
2019泰山学者青年专家
2019青岛市高层次人才服务绿卡
2018 The Editorial Board of Journal of Medicines Development Sciences
2018山东省高端化工产业委员会秘书长
2018山东省青年科技创新协会会员
2017 第十一届山东省青年科技奖
2017 山东省高等学校优秀科研成果奖一等奖
2017 长和国际奖教学金
2016 山东省自然科学杰出青年基金
2016 山东省自然科学学术创新奖
2016 青岛农业大学研究生创新计划
2014 青岛农业大学优秀学士论文指导教师
2015 青岛农业大学优秀学士论文指导教师
2015 The Advisory Board, Merck Index Online
2015 Asian Core Program Lectureship Award
2015 山东省高等学校优秀科研成果奖三等奖
2013 山东省高等学校优秀科研成果奖三等奖
2013青岛农业大学优秀学士论文指导教师
2012 中国科学院大连化物所科技创新奖
2010 第八届亚欧化学会议最佳墙报奖 (AES-MMEOS 2010)
2004 南开大学陈茹玉奖学金
研究兴趣与研究方向
面向国家重大战略需求和国际前沿重要科学问题,通过化学键的断裂与重组及多学科交叉与融合,解决新一代物质创造与转化过程中的重要科学问题,高效创造功能新分子,同时以合成化学为核心,面向能源、医药和材料从事相关交叉学科的研究。
Publications:
79. Wang Lin-Xuan, Qiu Bin, An Xiao-De, Dong Pei-Zhen, Liu Rui-Bin and Xiao Jian*, Organocatalytic Cascade Aldimine Condensation/[1,6]-Hydride Transfer/Mannich-Type Cyclization: Sustainable Access to Indole-2,3-Fused Diazocanes, Green Chem. 2021, 23, 8181. (IF = 10.182)
78. Yang Shuo, An Xiao-De,* Qiu Bin, Liu Rui-Bin, and Xiao Jian*, Access to Polycyclic Indole-3,4-Fused Nine-Membered Ring via Cascade 1,6-Hydride Transfer/Cyclization, Org. Lett. 2021, in press. (IF = 6.555)
77. An Xiao-De,* and Xiao Jian*, Recent Advances in Hydride Transfer-Involved C(sp3)–H Activation Reactions, Org. Chem. Front. 2021, 8, 1364. (IF = 5.455)
76. Yu Liping, Qiu Bin, Dong Peizhen, Xiao Jian * Yu Shitao*, Facile Synthesis of Spirocyclic Tetrahydroquinolines via C(sp3)–H Functionalization in a Cascade Redox Process, Synthesis 2021, in press.
75. Zhong-Xuan Qiu, Pei-Zhen Dong, Zhao Huai-Li, Zhao Mei-Fa, Qiu Bin,* and Xiao Jian*,
Brønsted Acid-Catalyzed Minisci-Type Cross-Dehydrogenative Coupling of N‑Heteroaromatics and Cyclic Ethers. J. Org. Chem. 2021, 86, 9299. (IF = 4.354)
74. Duan Kang, Shi Hongjin, Wang Lin-Xuan, Li Shuai-Shuai,* Xu Lubin and Xiao Jian*, Hydride Transfer Enabled Switchable Dearomatization of Indoles in the Carbocyclic Ring and the Pyrrole Ring, Org. Chem. Front. 2020, 7, 2511. (IF = 5.455)
73. Shen Yao-Bin, Wang Lin-Xuan, Sun Yun-Ming, Dong Feng-Ying, Yu Liping, Liu Qing, and Xiao Jian*, Hydride Transfer Initiated Redox-Neutral Cascade Cyclizations of Aurones: Facile Access to [6,5] Spirocycles, Org. Lett. 2020, 22, 2537. (IF = 6.555)
72. An Xiao-De, Yang Shuo, Qiu Bin, Yang Ting-Ting, Li Xian-Jiang, and Xiao Jian*, Photoredox-Enabled Synthesis of β‑Substituted Pyrroles from Pyrrolidines, J. Org. Chem. 2020, 85, 9558. (IF = 4.745)
71. Zhou Lan, An Xiao-De, Yang Shuo, Li Xian-Jiang, Shao Chang-Lun,* Liu Qing, Xiao Jian*, Organocatalytic Cascade β-C(sp3)−H Functionalization/Aromatization of Pyrrolidines via Double Hydride Transfer, Org. Lett. 2020, 22, 776. (IF = 6.555)
70. An Xiao-De and Xiao Jian*, Fluorinated Alcohols: Magic Reaction Medium and Promoters for Organic Synthesis, Chem. Rec. 2020, 20, 142. (IF = 5.387).
69. Shen Yao-Bin, Wang Lin-Xuan, Sun Yun-Ming, Dong Feng-Ying, Yu Li-Ping, Liu Qing, Xiao Jian*, J. Org. Chem. 2020, 85, 1915. (IF = 4.745)
68. Zhu Shuai, Chen Ye-Hui, Wang Yong-Bin, Yu Peiyuan, Li Shao-Yu, Xiang Shao-Hua,
Wang Jun-Qi, Xiao Jian, Bin Tan*, Organocatalytic Atroposelective Construction of Axially Chiral Arylquinones, Nat. Comm. 2019, 10, 4268. (IF = 12.353)
67. Wang Shuai, Shen Yao-Bin, Li Long-Fei, Qiu Bin, Liu Xicheng, Qing Liu, and Xiao Jian *, N-Alkylation-Initiated Redox-Neutral [5+2] Annulation of 3-Alkylindoles with o-Aminobenzaldehydes: Access to Indole-1,2-Fused 1,4-Benzodiazepines, Org. Lett. 2019, 21, 8904. (IF = 6.555)
66. Zhou Lan, Shen Yao-Bin, An Xiao-De, Li Shuai-Shuai,* Liu Qing and Xiao Jian*, Redox-Neutral β-C(sp3)−H Functionalization of Cyclic Amines via Intermolecular Hydride Transfer, Org. Lett. 2019, 21, 8543. (IF = 6.555)
65. Shen Yao-Bin, Li Long-Fei, Xiao Ming-Yan, Li Xian-Jiang, Yang Jian-Ming, Liu Qing, Xiao Jian*, Redox-Neutral Cascade Dearomatization of Indoles via Hydride Transfer: Divergent Synthesis of Tetrahydroquinoline-Fused Spiroindolenines, J. Org. Chem. 2019, 84, 13935. (IF = 4.745)
64. An Xiao-De, Duan Kang, Li Xian-Jiang,Yang Jian-Ming, Liu Qing, Xiao Jian*, Synthesis of Tetrahydro[1,3,4]triazepines via Redox-Neutral α‑C(sp3)−H Amination of Cyclic Amines, J. Org. Chem. 2019. 84, 11839. (IF = 4.745)
63. Sun Meng, Zhou Si-Jia, Lou Sai-Fan, Xiao Jian, Shi Feng*, Catalytic Asymmetric (4+3) Cyclizations of In Situ Generated ortho-Quinone Methides with 2-Indolylmethanols, Angew. Chem. Int. Ed. 2019, 58, 8703. (IF = 12.257)
62. Zhang Lei, Xiang Shao-Hua, Wang Jun, Xiao Jian, Wang Junqi, Tan Bin*, Phosphoric Acid Catalyzed Atroposelective Construction of Axially Chiral Arylpyrroles, Nat. Comm. 2019, 10, 566. (IF = 12.353)
61. Li Shuai-Shuai, Zhu Shuai, Chen Chunqi, Duan Kang, Liu Qing, Xiao Jian*, Hydride Transfer Involved Redox-Neutral Cascade Cyclizations for Construction of Spirocyclic Bisoxindoles Featuring a [3,4]-Fused Oxindole Moiety, Org. Lett. 2019, 21, 1058. (IF=6.579)
60. Zhu Shuai, Chen Chunqi, Duan Kang, Li Shuai-Shuai,* Liu Qing, Xiao Jian*, Cascade [1,5]-Hydride Transfer/Cyclization for Synthesis of [3,4]-Fused Oxindoles. Li Shuai-Shuai, J. Org. Chem. 2019, 84, 8440. (IF = 4.805)
59. Xu Lubin, Chen Haohua, Liu Jian, Zhou Lan, Lan Yu*, Xiao Jian*, Chiral Phosphoric Acid Catalyzed Asymmetric C(sp3)–H Functionalization of Biomass-Derived 2,5-Dimethylfuran via Two Sequential Cope-Type Rearrangements, Org. Chem. Front. 2019, 6, 1162. (IF = 5.455)
58. Shen Yao-Bin, Li Shuai-Shuai, Yun-Ming Sun, Yu Liping, Zhi-Hui Hao,* Liu Qing, Xiao Jian*, Organocatalytic C(sp3)−H Functionalization of 5-Methyl-2,3-dihydrofuran Derivatives with Trifluoropyruvates via Sequential exo-Tautomerization/Carbonyl-Ene Process, J. Org. Chem. 2019, 84, 2779. (IF = 4.805)
57. Shen Yao-Bin, Li Shuai-Shuai, Yun-Ming Sun,* Liu Xicheng, Yu Liping, Liu Qing, Xiao Jian*, Formal [4 + 2] Annulation of Oxindole-Embedded ortho-Quinone Methides with 1,3-Dicarbonyls: Synthesis of Spiro[Chromen-4,3´-Oxindole] Scaffolds, J. Org. Chem. 2019, 84, 3990. (IF = 4.805)
56. Shen Yao-Bin, Li Shuai-Shuai, Liu Xicheng, Yu Liping, Liu Qing, Xiao Jian*, A New Type of Oxindole-Embedded ortho-Quinone Methide: Dearomative [4+2] Cycloaddition with 2,5-Dimethylfuran, Adv. Syn. Catal. 2019, 361, 1453 (IF = 5.123)
55. Lv Xintong, Hu Fangzhi, Duan Kang, Li Shuai-Shuai, Liu Qing, Xiao Jian*, Aromatization-Driven Cascade [1, 5]-Hydride Transfer Reaction Promoted by Fluorinated Alcohols, J. Org. Chem. 2019, 84, 1833. (IF = 4.805)
54. Wang Shuai, An Xiao-De, Li Shuai-Shuai, Liu Xicheng, Liu Qing, Hydride Transfer Initiated Ring Expansion of Pyrrolidines toward Highly Functionalized Tetrahydro-1-benzazepines,
Xiao Jian,* Chem. Comm. 2018, 54, 3833. (IF = 6.290)
53. Yu Liping, Li Shuai-Shuai, Li Weina, Yu Shitao*, Liu Qing, Xiao Jian*, Fluorinated Alcohol Promoted Reaction of Chlorohydrocarbon with Diverse Nucleophiles for Synthesis of Triarylmethanes and Tetraarylmethanes, J. Org. Chem. 2018, 83, 15277. (IF = 4.805)
52. Li, Shuai-Shuai, Lv Xintong, Ren Didi, Shao Chang-Lun, Liu Qing, Xiao Jian*, Redox-Triggered Cascade Dearomative Cyclizations Enabled by Hexafluoroisopropanol, Chem. Sci. 2018, 9, 8253. (IF = 9.556)
51. Shen Yao-Bin, Li Shuai-Shuai, An Xiao-De, Liu Qing,Liu Xicheng, Xiao Jian*, Organocatalytic Dearomative [4 + 2] Cycloadditions of Biomass-Derived 2,5-Dimethylfuran with ortho-Quinone Methides: Access to Multi-Substituted Chromanes, Org. Lett. 2018, 20, 6069. (IF = 6.579)
50. Li Shuai-Shuai, Zhou Lan, Wang Liang, Zhao Huaili, Yu Liping, Xiao Jian*, Carbocation-Initiated Cascade [1,5]-Hydride Transfer/Cyclization: Facile Synthesis of dibenzo[b,e]azepines” Org. Lett. 2018, 20, 138. (IF = 6.579)
49. Zhu Shuai, Chen Chunqi, Xiao Mingyan, Yu Liping, Wang Liang*, Xiao Jian*, “Construction of the Tetrahydroquinoline Spiro Skeleton via Cascade [1,5]-Hydride transfer-involved C(sp3)-H Functionalization “on Water” Green Chem. 2017, 19, 5653. (IF = 8.586)
48. Xiao Mingyan, Ren Didi, Xu Lubin, Yu Liping and Xiao Jian*, “SN1-type Alkylation of N-Heteroaromatics with Alcohols” Org. Lett. 2017, 19, 5724. (IF = 6.579)
47. Li Shuai-Shuai, Fu Shiheng, Wang Liang, Xu Lubin and Xiao Jian*, “t-BuOK-Mediated Oxidative C(sp3)-H Arylation of 2-Alkylazaarenes with Nitroarenes” J. Org. Chem. 2017, 82, 8703. (IF = 4.849)
46. Xiao Jian*, Wen Hao, Wang Liang, Xu Lubin, Hao Zhihui, Shao Chang-Lun*, Wang Chang-Yun, “Catalyst-Free Dehydrative SN1-Type Reaction of Indolyl Alcohols with Diverse Nucleophiles on Water” Green Chem. 2016, 18, 1032. (IF = 8.586, Hot Paper, Highlighted by X-mol资讯网站,科技日报,中国网)
45. Wang Liang, Xiao Jian*, “Hydrogen-Atom Transfer Reactions”Topics in Current Chemistry, 2016, 374, 17. (IF=4.46, Invited Review)
44. Wang Liang, Xiao Jian*, “C(sp3)-H Bond Functionalization by Sequential Hydride Transfer/Cyclization: Electronic Effect and Steric Effect Controlled Regioselectivity”
Org. Chem. Front. 2016, 3, 635. (IF=4.69, Inside Front Cover, Hot Articles in March 2016)
43. Zhao Huaili, Xiao Mingyan, Wang Liang * and Xiao Jian *, “Bifunctional Thiourea Catalyzed Asymmetric Michael Addition of Anthrone to Methyleneindolinones”
RSC Adv. 2016, 6, 38588 (IF=3.108)
42. Liu Jian, Wang Xiaoxiao, Wang Liang, Xu Lubin, Hao Zhihui and Xiao Jian*, “Fluorinated Alcohol-Mediated [4+3] Cycloaddition Reaction of Indolyl Alcohols with Cyclopentadiene”Org. Biomol. Chem. 2016, 14, 11510. (IF = 3.564)
41. Dong Haoxun, Xu Lubin, Li Shuai-Shuai, Wang Liang, Shao Chang-Lun, Xiao Jian*, “Facile Synthesis of Azaarene-substituted Hydroxycoumarins Possessing High Biological Activities via Three-Component C(sp3)-H Functionalization”
ACS Comb. Sci. 2016, 18, 604. (IF=3.168)
40. Liu Jian, Wang Xiaoxiao, Xu Lubin, Hao Zhihui, Wang Liang* and Xiao Jian *, “One Step Synthesis of 2-Alkenylchromanes via Inverse Electron-Demand Hetero-Diels-Alder Reaction of o-Quinone Methide with Unactivated Dienes” Tetrahedron 2016, 72,7642. (IF = 2.651)
39. Zhao Huaili, Wang Xiaoxiao, Wang Liang* and Xiao Jian*, “Regioselective Michael Addition of Anthrone to Methyleneindolinones”
Synthesis, 2016, 48, 2112. (IF=2.650)
38. Fu Shiheng, Wang Liang, Dong Haoxun, Yu Junqiang, Xu Lubin and Xiao Jian*, “Facile Synthesis of 2-Alkenylazaarenes via Dehydrative Coupling of 2-Methylazaarenes with Aldehydes on Water”
Tetrahedron Lett. 2016, 57, 4533. (IF = 2.193)
37. Zhang Xianhui, Li Shuai-Shuai, Wang Liang, Xu Lubin, Xiao Jian *, Zhen-Jiang Liu*, 2-Methylquinoline Promoted Oxidative Ring-Opening of N-Sulfonyl Aziridines with DMSO: Facile Synthesis of α-Amino Aryl Ketones, Tetrahedron 2016, 72, 8073. (IF = 2.651)
36. Zhu Shuai, Xu Lubin, Wang Liang*, Xiao Jian*, “Recent Advances in Asymmetric Synthesis of Optically Active Indole Derivatives from 3-Indolylmethanols”
Chin. J. Org. Chem. 2016, 36, 1229. (IF=1.852)
35. Liu Qing, Dong Xu, Li Jun, Xiao Jian, Dong Yunhui,* and Liu Hui*, “Recent Advances on Palladium Radical Involved Reactions”
ACS Catal. 2015, 5, 6111 (IF=10.614)
34. Wen Hao, Wang Liang, Xu Lubin, Hao Zhihui, Shao Chang-Lun,* Wang Chang-Yun, Xiao Jian*, “Fluorinated Alcohol-Mediated SN1-Type Reaction of Indolyl Alcoholswith Diverse Nucleophiles”
Adv. Syn. Catal. 2015, 357, 4023 (IF = 5.646)
(VIP and Cover Picture, Highlighted by X-mol资讯网站,科技日报,中国网)
33. Wang Xiaoxiao, Liu Jian, Xu Lubin, Hao Zhihui, Wang Liang*, Xiao Jian*, “Friedel–CraftsAlkylation of Heteroarenes and Arenes with Indolyl Alcohols for Construction of 3,3-Disubstituted Oxindoles”
RSC Adv., 2015, 5, 101713. (IF=3.108)
32. Xu Lubin, Shao Zhuzhou, Wang Liang,Xiao Jian*, “Tandem sp3 C-H Activation/Decarboxylation of 2-Alkyl Azaarenes with Coumarin-3-Carboxylic Acid”
Org. Lett., 2014, 16, 796. (IF = 6.579)
31. Wang Liang, Xiao Jian*, “Advancement of Cascade [1,5]-Hydrogen Transfer/Cyclization: A Method for Direct Functionalization of Inactive C(sp3)-H Bonds”
Adv. Syn. Catal., 2014, 356, 1137. (IF = 5.646)
30. Xiao Jian,*Chen Yuye, Zhu Shuai,Wang Liang, Xu Lubin, Wei Hongtao, “Diversified Construction of Chromeno[3,4-c]pyridin-5-one and Benzo[c]chromen-6-one Derivatives by Domino Reaction of 4-alkynyl-2-oxo-2H-chromene-3-carbaldehydes”
Adv. Syn. Catal., 2014, 356, 1835. (IF = 5.646)
29. Wang Liang, Xiao Jian*,LohTeck-Peng*, “Organocatalyticβ-Functionalization of Saturated Carbonyl Compounds---The State of the Art”
ChemCatChem, 2014, 6, 1183.(IF = 4.803)
28. Shao Zhuzhou, Xu Lubin, Wang Liang, Wei Hongtao, Xiao Jian,* “Catalyst-free Tandem Michael Addition/Decarboxylation of (thio)coumarin-3-carboxylic Acids with Indoles: Facile Synthesis of Indole-3-substituted 3,4-dihydro(thio)coumarins”
Org. Biomol.Chem., 2014, 12, 2185. (IF = 3.564)
27. Wang Liang,Chen Yuye, Xiao Jian*, “AlkylideneindoleniniumIons and Alkylideneindolenine: Key Intermediates for Asymmetric Synthesis of 3-Substituted Indoles”
Asian J. Org.Chem. 2014, 3, 1036. (IF = 2.788)
26. Shao Zhuzhou, Wang Liang, Xu Lubin, Zhao Huaili and Xiao Jian *,“Facile Synthesis of Azaarene-2-substituted Chromanone Derivatives via Tandem sp3 C−H Functionlization/Decarboxylation of Azaarenes with 4-oxo-4H-chromene-3-carboxylic acid”
RSC Advances, 2014, 4, 53188. (IF = 3.108)
25. Xu Lubin, Shao Zhuzhou, Wang Liang, Zhao Huaili and Xiao Jian *,” Catalyst-Free Synthesis of (Z)-2-Alkenylquinoline Derivatives via C(sp3)-H Functionalization of 2-Methylquinolines” Tetrahedron Lett. 2014, 55, 6856. (IF = 2.35)
24. Yu Xinzhang, Yu Songjie, Xiao Jian, Wan Boshun, Li Xingwei*, “Rhodium(III)-Catalyzed Azacycle-Directed Intermolecular Insertion of Arene C−H Bonds into α-Diazocarbonyl Compounds”
J. Org. Chem. 2013, 78, 5444. (IF = 4.849)
23. Xiao Jian*, “Merging Organocatalysis with Transition Metal Catalysis: HighlyStereoselective Alkylation of Aldehydes”
Org. Lett. 2012, 14, 1716. (IF = 6.579) (Highlighted by Synfacts 2012, 8, 0749)
22. Xiao Jian*,“Oxidative Enamine Catalysis: Direct Catalytic Enantioselective β-Functionalization of Aldehydes”
ChemCatChem 2012, 4, 612. (IF = 4.803)
21. Liang Tao, Xiao Jian*, Xiong Zhiyi,Li Xingwei*, “Organocatalytic Asymmetric 1,4 Addition of Aldehydes to Acridiniums Catalyzed by a DiarylprolinolSilyl Ether”
J. Org. Chem. 2012, 77, 3583. (IF =4.849)
20. NiuRui, Xiao Jian*, Liang Tao, Li Xingwei*, “Facile Synthesis of Azaarene-Substituted 3-Hydroxy-2-Oxindoles via Bronsted Acid-Catalyzed sp3C-H Functionalization”
Org. Lett., 2012, 14, 676. (IF = 6.579)
19. Xiao Jian, Zhao Kai, LohTeck-Peng*,“The OrganocatalyticEnantioselective Acid Free Alkylation of Aldehydes in Fluorinated Alcohols”
Chem. Comm. 2012, 48, 3548. (IF = 6.57)
18. Huang Fen, Xu Lubin, Xiao Jian*, “OrganocatalyticEnantioselectiveDehydrogenative α-Alkylation of Aldehydes with Benzylic Compounds”
Chin. J. Chem. 2012, 30, 2721. (IF = 1.010)
(Invited Special Issue of "Asymmetric Synthesis", one of the most accessed papers from 11/2012 to 10/2013).
17. NiuRui, Yang Shiying, Xiao Jian*, Liang Tao, Li Xingwei*, “Yb(OTf)3-Catalyzed Addition of 2-methylAzaarenesto Isatins via C-H Functionalization”
Chin. J. Catal. 2012, 33, 1636. (IF = 2.813)
16. Wang Xiaowei, Li Xuting, Xiao Jian, Jiang Yi, Li Xingwei*, “Rh(III)-Catalyzed Oxidative Olefination of N-(Naphthalen-1-yl)amides”
Synlett, 2012, 1649. (IF = 2.151)
15. Xiao Jian, Zhao Kai, LohTeck-Peng*,“Highly Enantioselective Intermolecular Alkylation of Aldehydes with Alcohols by Cooperative Catalysis of DiarylprolinolSilyl Ether with Brønsted Acid” Chem. Asian J. 2011, 6, 2890. (IF = 4.083)
14. Xiao Jian and Li Xingwei*, “Gold a-Oxo Carbenoids in Catalysis: Catalytic O-Atom Transfer to Alkynes”
Angew. Chem. Int. Ed. 2011, 50, 7226. (IF = 12.1)
13. Xiao Jian, Lu Yun-Peng, Liu Yan-Ling, Wong Poh-Shen, LohTeck-Peng*, “A New Class of Structurally Rigid Tricyclic Chiral Secondary Amine Organocatalyst: Highly EnantioselectiveOrganocatalytic Michael Addition of Aldehydes to Vinyl Sulfones”
Org. Lett. 2011, 13, 876.(IF = 6.579)
12. Xiao Jian, Xu Feng-Xia, Lu Yun-Peng, Liu Yan-Ling, LohTeck-Peng*, “Highly Efficient and Modularly Tuned Bicyclic Organocatalyst for the Enantioselective Michael Addition of Aldehydes to Nitroalkenes”
Synthesis-Stuttgart, 2011, 1292. (IF = 2.650)
11. Xiao Jian, Xu Feng-Xia, Lu Yun-Peng, LohTeck-Peng*, “Chemzymes: A New Class of Structurally Rigid Tricyclic Amphibian Organocatalyst Inspired by Natural Product”
Org. Lett. 2010,12, 1220. (IF = 6.579) (Highlighted by Synfacts 2011, 5, 0561)
10. Xiao Jian, Wong Zhen-Zhou, Lu Yun-Peng, LohTeck-Peng*, “Hexahydropyrrolo[2,3-b]indoles: A New Class of Structurally Rigid Tricyclic Skeleton for Oxazaborolidine-Catalyzed Asymmetric Borane Reduction”
Adv. Synth. Catal. 2010, 352, 1107. (IF = 5.646)
9. Xiao Jian and Loh Teck-Peng*,“The OrganocatalyticEnantioselective Michael Addition of Aldehydes to Vinyl Sulfones in Water”
Synlett, 2010, 2029. (IF = 2.151)
8. Xiao Jian and Loh Teck-Peng*, “Design, Synthesis and Optical Resolution of New Bifunctional Ligand: 1,1′-Dimethyl-octahydro-8,8′-Biquinoline-7,7′-diol”
Org. Lett. 2009, 11, 2876. (IF = 6.579)
7. Xiao Jian and Loh Teck-Peng*, “Unexpected Domino Ring Closure: Highly Stereoselective Construction of a Tetracyclic Indole Alkaloid Ring System”
Tetrahedron Lett. 2008, 49, 7184. (IF = 2.193)
6. Xiao Jian and Loh Teck-Peng*, “Design and Synthesis of a Water-Tolerant Chiral Indium Complex: Application to One-Pot Three-Component Mannich-Type Reactions in Water”
Synlett, 2007, 815. (IF = 2.151)
5. Xiao Jian, Lu Yong-Na, Wang Guo-Cang, Li Jin-Shan et al., “3-(3H-Inden-1-ylmethyl)-2,2'-bis(methoxymethoxy)1,1'-binaphthalenyl”
Acta Crystallographica Section E, 2005, 61, O1501.
4. Wang Guo-Cang, Xiao Jian, Lu Yong-Na, et al., “Synthesis, Crystal Structures and in Vitro Antitumor Activities of Some Arylantimony Derivatives of Analogues of Demethylcantharimide”, J. Organomet. Chem., 2004, 689, 1631. (IF = 2.4)
3. Wang Guo-Cang, Xiao Jian, Lu Yong-Na, Li Jin-Shan, “Synthesis, Characterization and in Vitro Cytotoxicity Screening of Some Triarylbismuth(V) di(N-salicylidene) Amino Carboxylates and the Crystal Structure of (2-HOC6H4CH=NCH2CO2)2Bi(C6H5)3”
Appl. Organomet. Chem., 2005, 19, 113. (IF = 2.4)
2. Wang Guo-Cang, Lu Yong-Na, Xiao Jian, Li Jin-Shan, “Synthesis, Crystal Structures and in Vitro Antitumor Activities of Some Organoantimony Arylhydroxamates”
J. Organomet. Chem. 2005, 690, 151. (IF = 2.4)
1. Guo Qun-Sheng, Lu Yong-Na, Liu Bing, Xiao Jian, Li Jin-Shan, “A Facile Synthesis of 3 or 3,3′-Substituted Binaphthols and Their Applications in the Asymmetric Addition of Diethylzinc to Aldehydes”
J. Organomet. Chem. 2006, 691, 1282. (IF = 2.4)
授权专利:
13. 肖建,朱帅,李帅帅“一种基于氮原子α位氢迁移策略的吲哚碳环去芳香化合成方法”
专利号:ZL201810733984.2
12. 肖建,朱帅,李帅帅“一种氮杂环取代对醌骨架螺环化合物的合成方法”
专利号:ZL201810733970.0
11. 肖建,李帅帅,朱帅,“一种苯酚类化合物的苄基化合成方法”
专利号:ZL201810725188.4
10. 肖建,沈耀斌,“通过二甲基呋喃与含氧化吲哚邻羟基苄醇合成螺-色满-4,3′-氧化吲哚的合成方法” 专利号:ZL201810967990.4
9. 肖建,沈耀斌, 段康,“基于生物质源2, 5-二甲基呋喃去芳香化环加成策略构建多取代色满化合物的合成方法” 专利号:ZL201810927561.4
8. 肖建,朱帅,“一种合成吲哚取代或二茂铁取代氮杂芳烃的方法”
专利号:ZL 201710442072.5
7. 肖建,朱帅,“一种克霉唑的合成方法”
专利号:ZL201711098933.9
6. 肖建,朱帅,“一种八氢二吡咯并喹啉类化合物的制备方法”
专利号:ZL201711254567.1
5. 肖建,王帅,“一种基于靛红骨架的苯并[b,e]氮杂卓化合物及其制备方法”
专利号:ZL201810979889.0
4. 肖建,朱帅,“一种二苯并[b,e]吖庚因类化合物的制备方法”
专利号:ZL201711248907.X
3. 肖建,徐鲁斌,邵朱宙,“3-(1-芳基-2-(2-氮杂芳烃)乙基)-4-羟基香豆素及其制备方法”专利号:ZL201510679157.6
2. Loh Teck-Peng* and Xiao Jian “Process for Preparation of Octahydrobiquinoline Compounds”, PCT International Patent Application, 2010, 59pp. Patent Number: WO 2010132029
1. Loh Teck-Peng* and Xiao Jian “Preparation of Tricyclic Chiral Compounds and Their Use in Asymmetric Catalysis”, PCT International Patent Application, 2010, 141pp. Patent number: WO2010027334
课题组新闻 |
课题组简介
功能有机分子实验室成立于2013年3月,致力于发展绿色高效的物质转化合成方法学及功能有机分子的设计合成及应用。以绿色化学为核心,发展原子经济性的绿色有机合成化学。具体包括:(1)发展氢迁移策略的碳氢键活化及官能化反应;(2)新试剂制备及新反应发现;3. 新催化剂设计及新催化体系建立;4. 药物合成新工艺新路线开发;5. 活性分子活性评价,发现先导化合物。实验室面积400 m2,课题组成员教授3名,副教授2名,讲师1名,研究生14人,本科生10人。实验室拥有500M核磁共振仪、高效液相色谱仪、高效气相色谱仪、气相-质谱联用仪、旋光仪、低温反应仪以及常规有机合成设备,具备承担各项基础研究与应用研究的条件。本课题组热烈欢迎各高校、科研院所及企业与我们在功能分子的合成及应用等方面进行广泛的交流与合作。热烈欢迎优秀的本科生报考本课题组的研究生!热烈欢迎有志于投身科研事业的优秀博士加入我们的团队! 实验室办公电话:0532-88030975。
2015年
2014年
2013年
课题组老师
安孝德,邱斌, 孙云明,董凤英,于丽萍
在读研究生:
研究生三年级:杨烁、董培桢
研究生二年级:王忠霖、时亚飞、邵大营
研究生一年级:杨帆、范小梦、汪燕平、王惠芸
已毕业研究生:
2014 陈雨叶 去向:免试攻读澳门大学博士研究生
2015 邵朱宙 去向:免试攻读南京大学博士研究生
2016 赵怀丽 去向:齐鲁理工学院
2016 王潇潇 去向:青岛陆橘科技有限公司
2017 董浩训 去向:潍坊市康华生物技术有限公司
2017 付士恒 去向:鲁西集团股份有限公司
2017 任文录 去向:北京药素科技有限公司
2018 沈耀斌 去向:成都有机所
2018 周兰 去向:武汉大学
2018 肖明艳 去向:中国海洋大学
2019 段康 去向:暨南大学
2020 王琳璇 去向:山东大学
2020 李龙飞 去向:清原农冠
实验室及仪器设备照片
课题组学术交流及活动剪影
2019年12月6日,课题组长肖建教授主持的山东省自然科学杰出青年基金验收结题会议举行。会议邀请了国家杰青南方科技大学徐明华教授、长江学者东北师范大学张前教授、国家优青中科院北京化学研究所王从洋研究员、泰山学者特聘专家青岛科技大学于世涛教授、泰山学者特聘专家山东师范大学徐显秀教授作为专家评委,徐明华教授担任主席。
2019年12月6日,东北师范大学张前教授和中科院北京化学研究所王从洋研究院受邀访问本课题组并做学术报告。
2019年10月24日,课题组长肖建教授受邀参加山东科学大讲堂-齐鲁工业大学合成与催化研讨会并做学术报告。
2019年10月24日,课题组长肖建教授受邀参加山东科学大讲堂-齐鲁工业大学合成与催化研讨会并做学术报告。
2019年10月11-13日课题组长受邀参加第一届中新合成化学研讨会并做学术报告
2019年10月14-15日,新加坡国立大学赵宇教授访问本课题组并做学术报告
2018年12月29日,国家万人计划郝智慧团队与本课题组联合开展回顾2018展望2019思想提升培训会。青岛农业大学校党委王庆军书记受邀参会并就如何践行人生价值做重要指导。化学与药学院王进平教授和人文学院贾宝金教授分别就自己的科研感悟和科研工作中的法律实务做了报告,课题组长肖建教授则以“人生是一场修行”为题做了人生励志报告。
2018年11月14-17日,肖建教授参加在北京大学未名湖畔举行的山东省青年科技领军人才培训班。
2018年8月31日-9月1日,国家杰出青年基金获得者、青年千人计划南方科技大学谭斌教授,青年千人计划南开大学叶萌出教授,青年千人计划中国科技大学汪义丰教授,南京大学程旭教授,西湖学者杭州师范大学曾晓飞教授,青岛科技大学吕健教授访问课题组并做学术报告。
2015年11月26日课题组庆祝文浩同学获得国家奖学金
2015年中秋节课题组游驯虎山
2015年5月21日
江苏师范大学石枫教授访问本课题组并做学术报告
2015年5月12日到6月26日
美国南佛罗里达大学(The University of South Florida)
Jon Antilla教授在本课题组交流一个半月
2015年 课题组组织一系列爬山活动
2014年12月19-22日第十三届国际华人有机化学研讨会
2014年12月1日到5日课题组组长肖建教授受邀参加在马来西亚吉隆坡举行的第九届亚洲有机化学前沿国际研讨会(The 9th International Conference on Cutting-Edge Organic Chemistry in Asia)并荣获“Asian Core Program Lectureship Award”
“Asian Core Program Lectureship Award”是由亚洲有机化学前沿国际研讨会所设立的学术奖励。亚洲有机化学前沿国际研讨会是亚洲核心计划(Asian CORE Program,简称ACP)的组成部分,该计划由日本JSPS(Japan Society for the Promotion of Science)发起,日本、中国(包括台湾地区、香港地区)、新加坡,韩国、泰国等亚洲重要学术机构参与此计划的运作,旨在促进亚洲有机化学快速发展及加强各国科学家间的交流与合作。通过该奖励的资助,肖建教授将应邀在2015年赴新加坡进行一周的学术交流。
2014年10月26日课题组集体爬城阳七涧山活动
2014年9月27日课题组访问中科院合肥分院及强磁场科学中心
2014年8月23日美国南佛罗里达大学(The University of South Florida)
Jon Antilla教授访问课题组做学术报告并受聘我校客座教授
2014年8月30日
课题组集体游览青岛世界园艺博览会(青岛百果山森林公园)
2014年8月15日
Carlos F. Barbas III Memorial Symposium(Barbas Group Members)
2014年8月7日-10日
参加中科院上海有机所举办的国际会议“Challenges in Organic Chemistry”
2014年8月3日中国科学院强磁场科学中心青年千人计划刘青松研究员来实验室访问交流并做学术报告
2014年7月11日重庆大学王建华教授来实验访问交流
2014年6月19日美国威斯康辛大学麦迪逊分校(University of Wisconsin-Madison)药学院唐维平教授来实验室访问交流
2014年6月15日到17日参加在山东大学举办的第十届中美华人教授会议
2014年5月27日美国德克萨斯大学休斯顿医学中心药物研究中心主任安志强教授访问我院并受聘我校特聘教授
2014年5月17日本课题组与中国海洋大学邵长伦课题组第一次合作交流会议成功举办!
2014年1月美国加利福尼亚州圣地亚哥The Scripps Research Institute (TSRI)中国校友会合影留念
2013年5月17日本课题组举办手性催化与绿色有机合成论坛
专家参观实验
2013年5月17日LohTeck-Peng教授受聘为青岛农业大学客座教授
2013年5月22日美国匹兹堡大学Paul E. Floreancig教授来访
2013年5月30日中国科技大学郭庆祥教授,清华大学王梅祥教授,
四川大学冯小明教授,中国科学院理化技术研究所吴骊珠研究员来访
2013年10月25日新加坡南洋理工大学Yonggui Robin Chi教授,
河南大学黄河学者Hongjun Liu教授来访并做邀请报告。
2013年6月参加第二届“天然产物全合成--青年学术研讨会”
2012年10月课题组参加在北京大学举办的全国金属有机化学会议
2013年9月课题组集体爬青岛毛公山游玩