化学工程与技术研究生导师刘志海简介

  刘志海,男,1985年04月生,博士,副教授,硕士生导师

  研究方向:

  从事药学、中药学、微生物学方面的中药研发和细菌耐药性形成与防控技术研究

  学习工作经历:(从大学起,含博后、访学经历)

  2022年04月至今:青岛农业大学,化学与药学院,副教授

  2018年09月至2022年03月:青岛农业大学,化学与药学院,讲师

  2013年09月至2018年07月:中国农业大学(硕博连读),药理与毒理学,博士

  2009年09月至2013年07月:山东农业大学,制药工程,工学学士

  科学研究:

  主持及参与课题情况

  主持国家自然科学基金面上项目1项(32172911,58万),山东省自然科学基金1项(ZR2020QC199,15万),中国博士后科学基金面上项目1项(2021M701105,8万),青岛农业大学人才启动基金1项及企业横向课题2项;同时参与多项科学基金及课题。

  代表性成果列表(近五年,按时间倒序排列)

  目前已在Nat Microbiol、Adv Sci、J Hazard Mater、Environ Int、mBio、J Antimicrob Chemother、Antimicrob Agents Chemother等国际期刊发表科研论文近30篇,其中SCI论文20余篇;以一作或通讯作者发表SCI 论文10余篇。近五年代表作如下:

  1. Li X, Liu Z(并列一作), Wang J, Zhang Y, Tang H, Allardice PJ, Song Z, Qian B. Antibacterial activity of a nonmetal z-scheme heterojunction photocatalyst. J Photoch Photobio A. 2022:114019.

  2. Liu Z, Wang K, Zhang Y, Xia L, Zhao L, Guo C, Liu X, Qin L, Hao Z. High prevalence and diversity characteristics of blaNDM, mcr, and blaESBLS harboring multidrug-resistant Escherichia coli from chicken, pig, and cattle in China. Front Cell Infect Mi. 2022:1364.

  3. Liu Z, Wang W, Zhang Z, Sun L, Wu S. Natural antibacterial and antivirulence alkaloids from macleaya cordata against methicillin-resistant Staphylococcus aureus. Front Pharmacol. 2022;13:813172.

  4. Zhu X, Zhang Y, Shen Z, Wang W, Hao Z, Liu Z(通讯). Characterization of NDM-1-Producing Carbapenemase in Proteus mirabilis among broilers in China. Microorganisms. 2021;12:2443. DOI: 10.3390/microorganisms9122443.

  5. Li W, Liu Z(并列一作), Yin W, Yang L, Qiao L, Song S, Ling Z, Zheng R, Wu C, Wang Y. MCR expression conferring varied fitness costs on host bacteria and affecting bacteria virulence. Antibiotics. 2021;10:872.

  6. Liu Z, Guo C, Zhang Y, Zhao L, Hao Z. Rapid and sensitive detection of the colistin resistance gene mcr-3 by loop-mediated isothermal amplification and visual inspection. Microb Drug Resist. 2021;27:1328-1335.

  7. Yin W, Ling Z, Dong Y, Qiao L, Shen Y, Liu Z, Wu Y, Li W, Zhang R, Walsh TR. Mobile colistin resistance enzyme mcr‐3 facilitates bacterial evasion of host phagocytosis. Adv Sci. 2021:2101336.

  8. Fu Y, Chen Y, Liu D, Yang D, Liu Z, Wang Y, Wang J, Wang X, Xu X, Li X. Abundance of tigecycline resistance genes and association with antibiotic residues in Chinese livestock farms. J Hazard Mater. 2021;409:124921.

  9. Guan N, Liu Z(并列一作), Zhao Y, Li Q, Wang Y. Engineered biomaterial strategies for controlling growth factors in tissue engineering. Drug Deliv. 2020;27:1438-1451.

  10. Zhai R, Fu B, Shi X, Sun C, Liu Z, Wang S, Shen Z, Walsh TR, Cai C, Wang Y. Contaminated in-house environment contributes to the persistence and transmission of NDM-producing bacteria in a Chinese poultry farm. Environ Int. 2020;139:105715.

  11. Liu Z, Zhang R, Li W, Yang L, Liu D, Wang S, Shen J, Wang Y. Amino acid changes at the VIM-48 C-terminus result in increased carbapenem resistance, enzyme activity and protein stability. J Antimicrob Chemoth. 2019;74:885-893.

  12. Liu Z, Piccirilli A, Liu D, Li W, Wang Y, Shen J. Deciphering the role of V88L substitution in NDM-24 Metallo-β-Lactamase. Catalysts. 2019;9:744.

  13. Chen Y, Liu Z(并列一作), Zhang Y, Zhang Z, Lei L, Xia Z. Increasing prevalence of ESBL-producing multidrug resistance Escherichia coli from diseased pets in Beijing, China from 2012 to 2017. Front Microbiol. 2019;10:2852.

  14. He T, Wang R, Liu D, Walsh TR, Zhang R, Lv Y, Ke Y, Ji Q, Wei R, Liu Z, ..., Shen J, Wang Y. Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans. Nat Microbiol. 2019;4:1450-1456.

  15. Liu Z, Li J, Wang X, Liu D, Ke Y, Wang Y, Shen J. Novel variant of New Delhi Metallo-β-lactamase, NDM-20, in Escherichia coli. Front Microbiol. 2018;9:248.

  教学授课情况:

  主讲《生药学》、《药用植物学》、《中药学》、《药用植物学与生药学》、《天然药物化学》等课程

  获奖及社会兼职等情况:

  中国畜牧兽医学会兽医药理与毒理学分会理事,福建省科技特派员,青岛市科技特派员等

  已培养研究生情况:

  已培养(包括联培)5名

  邮箱:banyuanjun58@163.com

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